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26 February 2027 · Thessaloniki

BIOHackathon

Computational biology takes on antimicrobial resistance

A hackathon where students, researchers and professionals collaborate to tackle real challenges in antimicrobial resistance, using computational biology tools.

Computational biology & protein structure PDB 1AKE
  • 26 February 2027 Main event
  • Thessaloniki Regional Council Chamber
  • 4 thematic areas One shared challenge
  • €3,000 Total prize money
The idea

A challenge linking health, food and the environment.

Antimicrobial resistance makes infections harder to treat and affects many sectors. At BIOHackathon, teams study specific protein targets and explore evidence-based approaches using computational tools.

Why computational biology tools?

Computational biology tools make it possible to analyse biological data and investigate proteins and mechanisms associated with antimicrobial resistance.

Computational findings require careful interpretation and do not replace experimental validation.

The challenges

Four areas. One shared mission.

Each team chooses a thematic area and develops a scientifically grounded approach using real data.

  • A / HEALTH

    Antibiotic resistance

    Investigation of molecular mechanisms and proteins associated with bacterial resistance to antibiotics, using computational biology tools.

    Indicative research question:How do specific mutations in the structure of a carbapenemase, such as KPC, affect its ability to inactivate antibiotics?

  • B / FOOD

    Resistance in pathogens

    Study of pathogenic microorganisms and their resistance mechanisms, with a focus on food safety and protecting human health.

    Indicative research question:How can structural differences in resistance enzymes, such as CTX-⁠M-⁠15, be used to understand the resistance of bacteria that may occur in the food chain?

  • C / AGRICULTURE

    Antifungal resistance

    Investigation of the molecular mechanisms by which pathogenic fungi develop resistance to antifungal substances, affecting agricultural production and potentially public health.

    Indicative research question:How do mutations in the CYP51 protein affect the effectiveness of azole antifungal substances?

  • D / LIVESTOCK

    Antimicrobial resistance

    Study of the mechanisms by which antimicrobial resistance emerges and spreads in livestock farming, taking into account interactions between animals, humans, food and the environment.

    Indicative research question:How can genetic and protein data be used to identify shared resistance mechanisms in bacteria found in farmed animals and humans?

The One Health approach: These four themes do not exist in isolation. Resistance can connect people, animals, food and the environment.

Important note

The research questions presented in each thematic area are strictly illustrative and aim to highlight possible directions for investigation.

They are not mandatory requirements, do not restrict the scope of proposals, and do not require the use of specific proteins, organisms, data or computational tools.

Participants are free to formulate their own research question, choose their methodology and propose innovative approaches, provided these are meaningfully connected to one of the four thematic challenges and comply with the terms of participation.

One Health

How are they connected?

The four themes are different sides of a shared challenge. Choose a connection to explore it.

  • Food and Health The same families of resistance enzymes are found in hospitals and the food supply chain.
  • Agriculture to Health CYP51A mutations associated with azole use in crops can cause resistance to clinical antifungals.
  • Livestock to Health The mcr-1 gene has spread from pig farms to human clinical isolates.
Participation

From registration to a team solution.

You do not need to have a team already. You can join with an existing team or be placed in a new one.

  1. Step 1: Register individually

    Provide your details and interests. If you already have a team, enter its name.

    Registration form (opens in a new tab)

  2. Step 2: Choose a challenge

    Work in a team of two to five people, with support from scientific and technical mentors.

  3. Step 3: Develop and present

    Analyse data, document your approach and present your results at the main event.

Participation is free.

Timeline

Key milestones.

Preparation takes place before the final event. Teams are formed, develop an idea with their mentors and submit their solutions, which the Jury evaluates.

Dates may be updated by the organisers.

  1. Registration

    Website launch – Registration opens

  2. Registration

    Registration deadline

  3. Teams

    Team formation

  4. Teams

    Participants are informed of their team

  5. Mentoring

    Kick Start meetings of the teams with their mentors begin

  6. Mentoring

    Kick Start meetings of the teams with their mentors end

  7. Submissions

    Proposal submission deadline

  8. Evaluation

    The Jury completes the evaluation of the proposals

  9. Event

    Final event

Evaluation

What do teams present?

Each team presents its proposal in 10 minutes. The presentation should explain the problem, methodology, results and significance of the solution.

Prizes

€3,000 in total

Three teams will receive cash prizes.

  1. 1st prize

    €1,500

  2. 2nd prize

    €1,000

  3. 3rd prize

    €500

Each prize is shared equally among the team’s members and paid into each member’s bank account. Terms of participation, Article 11

Evaluation criteria

Four evaluation criteria

Each criterion is scored from 0 to 10; the final score is the weighted sum.

  1. A.

    Relevance to the chosen challenge / Scientific and technical validity / Feasibility and potential impact

    Weight: 35%

  2. B.

    Innovation and originality

    Weight: 25%

  3. C.

    Sound and meaningful use of AI tools / Quality and documentation of the open-source code produced

    Weight: 20%

  4. D.

    Quality of the presentation and documentation of the solution

    Weight: 20%

In the event of a tie, the team with the higher score in criterion A ranks first; if the tie remains, criterion D decides.

For those who want to explore further

Scientific and practical support.

Technical details need not overwhelm first-time visitors. They are gathered in the preparation resources.

  • Guide to computational biology tools

    From protein sequence to structure prediction and evaluation, including key points for interpreting results.

  • Toolbox

    Protein databases, structural analysis tools and references to support your work.

  • Mentors

    Scientific and technical guidance as each team shapes and develops its approach.

Frequently asked questions

Who can participate?

The hackathon welcomes students, researchers and professionals interested in biology, artificial intelligence and data analysis. Participants must be aged 18 or over.

Do I need a team?

No. You may join with an existing team or register individually so the organisers can assign you to a team.

Can I participate as a mentor?

Yes. Mentors register separately, as scientific or technical mentors, using the mentor registration form (opens in a new tab).

Where will the event take place?

In person in the Regional Council Chamber (64 26is Oktovriou St., 546 27 Thessaloniki).

All frequently asked questions
Contact

We’re here to help

Have questions about the event? See the contact details below.

  • Email

    biohackathon@pkm.gov.gr

    General questions, registration enquiries and partnerships

  • Address

    Region of Central Macedonia, 64 26is Oktovriou St., 546 27 Thessaloniki, Greece

    For correspondence and visits

Organisers

The organising institutions

BIOHackathon is co-organised by ten institutions.

Terms of participation

Who can take part and how

Participation is free and open to students, researchers and professionals aged 18 or over. Teams have two to five members. You can register as part of an existing team or individually, with the option to be assigned to a team by the organisers.

Committees / Mentors

Scientific guidance and evaluation

The event is supported by the Organising and Scientific Committees. The Jury evaluates submissions, while mentors support the teams.

Next step

Interested in joining?

Registration is through the organisers’ forms. Every participant fills in the participant form individually; those who already have a team give its name. Mentors fill in the mentor form.